Dr. Kanwarpal Singh – Faculty of Engineering
Headshot of Kanwarpal-Singh

Dr. Kanwarpal Singh

Expertise

Optical coherence tomography, hyperspectral imaging, confocal microscopy, endoscopy, multiphoton microscopy

Research Clusters

  • Associate Professor

    Electrical & Computer Engineering

Overview

The focus of Dr. Singh’s lab is to develop novel endoscopic devices to image internal organs of the body. These endoscopes are based on optical imaging techniques such as optical coherence tomography, hyperspectral imaging, multiphoton imaging, etc.

Dr. Singh is currently working as Assistant Professor with the Department of Electrical and Computer Engineering, McMaster University. Before joining McMaster University, Dr. Singh lead an independent research group (Microendoscopy) at the Max Planck Institute for the Science of Light, Germany. His research group focused on the development of miniaturized flexible endoscopic devices for in vivo imaging. He finished his Ph.D. from INRS, Canada in 2013. He was a postdoctoral fellow at Harvard Medical School, USA until 2018 where he worked on the development of high-resolution optical coherence tomography systems. He was the recipient of the Doctoral research award from FRSQ and FQRNT. He also received Postdoctoral fellowships from FRSQ and CIHR. He has won several prestigious awards such as Innovation challenge award from Natural Sciences and Engineering Research Council (NSERC) of Canada.

  • BSc (Kurukshetra University, India)
  • MTech (Devi Ahilya University, India)
  • PhD (University of Quebec, Canada)

1. Innovation challenge award, Natural Sciences and Engineering Research Council (NSERC) of Canada, 2012

2. Innovation Award, Institut national de la recherche scientifique, Quebec, Canada. 2012

3. STELLA travel grant Italy, 2011

4. Incubic/Milton Chang travel grant, Optical Society of America, 2009

5. Ministère de l’Éducation, du Loisir et du Sport (MELS) travel grant 2009

  1. Romodina, M. N., A. Parmar and K. Singh (2024). “In vivo measurement of the biomechanical properties of human skin with motion-corrected Brillouin microscopy.” Biomedical Optics Express 15(3): 1777-1784.
  2. Parmar, A. and K. Singh (2024). “Motion-artifact-free single shot two-beam optical coherence elastography system.” Journal of Biomedical Optics 29(2): 025003-025003.
  3. Wu, X., R. Ishrak, R. Reihanisaransari, Y. Verma, B. Spring, K. Singh and R. Reddy (2024). “High-speed forward-viewing optical coherence tomography probe based on Lissajous sampling and sparse reconstruction.” Optics Letters 49(13): 3652-3655.
  4. Julia Kolb, Vasiliki Tsata Nora John, Kyoohyun Kim, Conrad Möckel, Gonzalo Rosso, Veronika Kurbel, Asha Parmar, Gargi Sharma, Kristina Karandasheva, Shada Abuhattum, Olga Lyraki, Timon Beck, Paul Müller, Raimund Schlüßler, Renato Frischknecht, Anja Wehner, Nicole Krombholz, Barbara Steigenberger, Dimitris Beis, Aya Takeoka, Ingmar Blümcke, Stephanie Möllmert, Kanwarpal Singh, Jochen Guck, Katja Kobow & Daniel Wehner. (2023). “Small leucine-rich proteoglycans inhibit CNS regeneration by modifying the structural and mechanical properties of the lesion environment.” Nature Communications. 14: 6814.
  5. Parmar, A., G. Sharma, and K. Singh (2022). “Polarization Independent Optical Coherence Tomography.” IEEE Photonics Journal. 14(2).
  6. J. Dong, C. Grant, B. Vuong, N.Nishioka, A.H. Gao, M. Beatty, G. Baldwin, A, Baillargeon, A. Bablouzian, P. Grahman, N. Bhat, E. Ryan, A. Barrios, S. Giddings, T. Ford, E. Beaulieu-Ouellet, S. Hosseiny, I. Lerman, W. Trasischker, R. Reddy, K. Singh, M. Gora, D. Hyun, L. Quénéhervé, M. Wallace, H. Wolfsen, P. Sharma, K. Wang, C. Leggett, J. Poneros, J. Abrams, C, Lightdale, S. Leeds, M. Rosenberg and G.J. Tearney, G.J. (2022). “Feasibility and Safety of Tethered Capsule Endomicroscopy in Patients With Barrett’s Esophagus in a Multi-Center Study.” Clinical Gastroenterology and Hepatology 20(4): 756-765.e3.
  7. Sharma, G. and K. Singh (2023). “Ultralong Imaging Range Chromatic Confocal Microscopy.” Advanced Photonics Research 4(1): 2200116.
  8. Sharma, G., A. Parmar, F. Hoffmann, K. Geißler, F. von Eggeling, O. Guntinas-Lichius and K. Singh (2022). “A proposal to perform high contrast imaging of human palatine tonsil with cross polarized optical coherence tomography.” Photonics. 9(4).
  9. Parmar, A., G. Sharma, A. Ramming and K. Singh (2022). “Deep tissue characterization with optical coherence elastography: a comparison of different methods.” Materials 15(23): 8558.
  10. Hartl, G., A. Parmar, G. Sharma and K. Singh (2022). “Cross-Polarized Optical Coherence Tomography System with Unpolarized Light.” Photonics. 9(2).
  11. Romodina, M. N. and K. Singh (2022). “Depth of focus extension in optical coherence tomography using ultrahigh chromatic dispersion of zinc selenide.” Journal of Biophotonics 15(8): e202200051.
  12. Romodina, M. N., K. Blessing and K. Singh (2022). “Polarization maintaining fiber-based depth encoded cross-polarized optical coherence tomography.” IEEE Access 10: 132685-132691.
  13. Parmar, A., G. Sharma, S. Sharma and K. Singh (2021). “Portable optical coherence elastography system with flexible and phase stable common path optical fiber probe.” IEEE Access 9: 56041-56048.
  14. Sharma, G., O. M. Thoma, K. Blessing, R. Gal, M. Waldner and K. Singh (2021). “Smartphone‐based multimodal tethered capsule endoscopic platform for white‐light, narrow‐band, and fluorescence/autofluorescence imaging.” Journal of Biophotonics 14(2): e202000324.
  15. Sharma, G., S. K. Naveed, A. Parmar and K. Singh (2021). “Chromatic dispersion based wide-band, fiber-coupled, tunable light source for hyperspectral imaging.” IEEE Access 9: 50538-50545.
  16. Blessing, K., J. Schirmer, A. Parmar and K. Singh (2021). “Depth encoded input polarisation independent swept source cross-polarised optical coherence tomography probe.” Journal of Physics D: Applied Physics 54(30): 305401.
  17. Blessing K., Schirmer J., Sharma G., Singh K. (2020). “Novel input polarisation independent endoscopic cross-polarised optical coherence tomography probe.” Journal of Biophotonics. 13(12): e202000134.
  18. Sharma, S., G. Hartl, S. K. Naveed, K. Blessing, G. Sharma and K. Singh (2020). “Input polarization-independent polarization-sensitive optical coherence tomography using a depolarizer.” Review of Scientific Instruments 91(4).
  19. MM Chowdhury, K Singh, MS Albaghdadi, H Khraishah, A Mauskapf, CW Kessinger, EA Osborn, S Kellnberger, Z Piao, L Cardenas, MS Grau, MR Jaff, K Rosenfield, P Libby, ER Edelman, ME Lindsay, GJ Tearney and FA Jaffer (2020). “Paclitaxel drug-coated balloon angioplasty suppresses progression and inflammation of experimental atherosclerosis in rabbits.” Basic to Translational Science 5(7): 685-695.
  20. Sharma, G., S. Sharma, K. Blessing, G. Hartl, M. Waldner and K. Singh (2020). “Swept source cross-polarized optical coherence tomography for any input polarized light.” Journal of Optics 22(4): 045301.
    Blessing, K., S. Sharma, A. Gumann and K. Singh (2019). “Low cost scalable monolithic common path probe design for the application in endoscopic optical coherence tomography.” Engineering Research Express 1(2): 025008.
  21. Gardecki, J. A., K. Singh, C.-L. Wu and G. J. Tearney (2019). “Imaging the human prostate gland using 1-μm-resolution optical coherence tomography.” Archives of Pathology & Laboratory Medicine 143(3): 314-318.
  22. Liang, C.-P., J. Dong, T. Ford, R. Reddy, H. Hosseiny, H. Farrokhi, M. Beatty, K. Singh, H. Osman and B. Vuong (2019). “Optical coherence tomography-guided laser marking with tethered capsule endomicroscopy in unsedated patients.” Biomedical Optics Express 10(3): 1207-1222.
  23. Otuya, D. O., G. Sharma, G. J. Tearney and K. Singh (2019). “All fiber polarization insensitive detection for spectrometer-based optical coherence tomography using optical switch.” OSA Continuum 2(12): 3465-3469.
  24. Singh, K., R. Reddy, G. Sharma, Y. Verma, J. A. Gardecki and G. Tearney (2018). “In‐line optical fiber metallic mirror reflector for monolithic common path optical coherence tomography probes.” Lasers in Surgery and Medicine 50(3): 230-235.
  25. Singh, K., G. Sharma and G. J. Tearney (2018). “Estimation and compensation of dispersion for a high-resolution optical coherence tomography system.” Journal of Optics 20(2): 025301.
  26. Singh, K., D. Yamada and G. Tearney (2017). “Astigmatism corrected common path probe for optical coherence tomography.” Lasers in Surgery and Medicine 49(3): 312-318.
  27. Yin, B., K. K. Chu, C.-P. Liang, K. Singh, R. Reddy and G. J. Tearney (2016). “μOCT imaging using depth of focus extension by self-imaging wavefront division in a common-path fiber optic probe.” Optics Express 24(5): 5555-5564.
  28. Chu, K. K., C. Unglert, T. N. Ford, D. Cui, R. W. Carruth, K. Singh, L. Liu, S. E. Birket, G. M. Solomon and S. M. Rowe (2016). “In vivo imaging of airway cilia and mucus clearance with micro-optical coherence tomography.” Biomedical Optics Express 7(7): 2494-2505.
  29. Ibrahim, A., G. Sharma, K. Singh and T. Ozaki (2016). “Terahertz detection based on spectral-domain interferometry using Mach-Zehnder interferometer.” Journal of Infrared, Millimeter, and Terahertz Waves 37: 837-845.
  30. Ibrahim, A., G. Sharma, K. Singh, M. Turmel and T. Ozaki (2016). “Ultra-high dynamic range electro-optic sampling for detecting millimeter and sub-millimeter radiation.” Scientific Reports 6: 23107.
  31. Singh, K., D. Yamada and G. Tearney (2015). “Common path side viewing monolithic ball lens probe for optical coherence tomography.” Modern Technologies in Medicine 7(1): 29-33.
  32. Jay, L., J.-M. Bourget, B. Goyer, K. Singh, I. Brunette, T. Ozaki and S. Proulx (2015). “Characterization of tissue-engineered posterior corneas using second-and third-harmonic generation microscopy.” PLoS One 10(4): e0125564.
  33. Sharma, G., K. Singh, A. Ibrahim, I. Al-Naib, R. Morandotti, F. Vidal and T. Ozaki (2013). “Self-referenced spectral domain interferometry for improved signal-to-noise measurement of terahertz radiation.” Optics Letters 38(15): 2705-2707.
  34. Singh, K., N. Haydari, I. Brunette and S. Costantino (2013). “Preparing uniform-thickness corneal endothelial grafts from donor tissues using a non-amplified femtosecond laser.” PLoS One 8(12): e83185.
  35. Dion, C., K. Singh, T. Ozaki, M. R. Lesk and S. Costantino (2013). “Analysis of pulsatile retinal movements by spectral-domain low-coherence interferometry: influence of age and glaucoma on the pulse wave.” PLoS One 8(1): e54207.
  36. Sharma, G., K. Singh, I. Al-Naib, R. Morandotti and T. Ozaki (2012). “Terahertz detection using spectral domain interferometry.” Optics Letters 37(20): 4338-4340.
  37. Singh, K., C. Dion, A. G. Godin, F. Lorghaba, D. Descovich, M. Wajszilber, T. Ozaki, S. Costantino and M. R. Lesk (2012). “Pulsatile movement of the optic nerve head and the peripapillary retina in normal subjects and in glaucoma.” Investigative Ophthalmology & Visual Science 53(12): 7819-7824.
  38. Singh, K., C. Dion, M. Lesk, T. Ozaki and S. Costantino (2011). “Spectral-domain phase microscopy with improved sensitivity using two-dimensional detector arrays.” Review of Scientific Instruments 82(2).
  39. Ferri, F., A. D’Angelo, M. Lee, A. Lotti, M. Pigazzini, K. Singh and R. Cerbino (2011). “Kinetics of colloidal fractal aggregation by differential dynamic microscopy.” The European Physical Journal-Special Topics 199(1): 139-148.
  40. Singh, K., C. Dion, M. Wajszilber, T. Ozaki, M. R. Lesk and S. Costantino (2011). “Measurement of ocular fundus pulsation in healthy subjects using a novel Fourier-domain optical coherence tomography.” Investigative Ophthalmology & Visual Science 52(12): 8927-8932.
  41. Mazzaferri, J., D. Kunik, J. Belisle, K. Singh, S. Lefrançois and S. Costantino (2011). “Analyzing speckle contrast for HiLo microscopy optimization.” Optics Express 19(15): 14508-14517.
  42. Singh, K., C. Dion, S. Costantino, M. Wajszilber, M. Lesk and T. Ozaki (2010). “Development of a novel instrument to measure the pulsatile movement of ocular tissues.” Experimental Eye Research 91(1): 63-68.
  43. Jay, L., A. Brocas, K. Singh, J.-C. Kieffer, I. Brunette and T. Ozaki (2008). “Determination of porcine corneal layers with high spatial resolution by simultaneous second and third harmonic generation microscopy.” Optics Express 16(21): 16284-16293.
  44. Rivas, L. M., K. Singh, A. Carballar and J. Azaña (2007). “Arbitrary-order ultrabroadband all-optical differentiators based on fiber Bragg gratings.” IEEE Photonics Technology Letters 19(16): 1209-1211.