Dr. P. Ravi Selvaganapathy – Faculty of Engineering
Ravi Selvaganapathy

Dr. P. Ravi Selvaganapathy

Expertise

Micro/Nanofabrication, bioprinting, biomedical microdevices, microelectromechanical systems, microfluidics, medical and environmental sensors, smart textiles. biomaterials, artificial organs

Areas of Specialization

Research Clusters

Current status

  • Accepting graduate students

  • Distinguished Engineering Professor, Canada Research Chair in Biomicrofluidics (laureate)

    Mechanical Engineering

  • Co-Director (Engineering)

    McMaster School of Biomedical Engineering

  • Professor

    McMaster School of Biomedical Engineering

Overview

Our expertise is in the microfabrication technology and in microfluidics. We are interested in developing fabrication and integration processes for new materials in microdevices. We are also interested in developing components such as micropumps, microvalves, micromixers and microfluidic nozzles that could be used in a number of applications. We apply this expertise to build innovative micro and nanoscale devices for use in environmental and medical diagnostics, drug discovery, drug delivery and for manufacture of artificial organs.

Specific Research Interests

  • Environmental sensors and continuous monitoring systems
  • Medical diagnostic sensors and lab on chip devices
  • Microfluidic devices for drug discovery and high throughput screening
  • Artificial Organs
  • Biofabrication and Cultivated Meat
  • 3D printing of silicones and reactive polymers
  • Additive manufacturing methods for sensors and microfluidic devices
  • Smart textiles and protective wearables

B.S, Central Electrochemical Research Institute, India,1998;

M.S, Ph.D, University of Michigan, U.S.A. 2002;

Post Doctoral Research, Sandia National Laboratories, U.S.A. 2004.

  • Editor’s Pick Award, Biomicrofluidics Journal (2018)
  • Dean’s Honor Roll in Graduate Supervision (2018)
  • Canada Research Chair Award (Tier II), Canada Research Chairs Program, (2016)
  • Best Paper Award – Basic Science and Technology- Journal of Endodontics (2016)
  • NSERC Discovery Accelerator Supplement Award (2015)
  • Best Paper Award – Chemical Sensors – IEEE Sensors Conference (2014)
  • McMaster Synergy Award for Interdisciplinary Collaboration (2014)
  • Dean’s Honor Roll for Teaching (2014)
  • Rising Star in Global Health Award, Grand Challenges Canada, (2012)
  • Canada Research Chair Award (Tier II), Canada Research Chairs Program, (2011)
  • Early Researchers Award, Ontario Ministry of Research and Innovation, (2010)

  1. S. Jalali, P.R. Selvaganapathy, A self-assembly and cellular migration based fabrication of high-density 3D tubular constructs of barrier forming membranes, Lab on Chip (2024) (accepted)
  2. M. Darestani-Farahani, I.M. Montealegre, M.T. Gilavan, T. Kirby, P.R. Selvaganapathy, P. Kruse, A highly sensitive ion-selective chemiresistive sensor for online monitoring of lead ions in water, Analyst, (2024) (accepted)
  3. S. Shahriari, P.R. Selvaganapathy, Isoelectric trapping and discrimination of histones from plasma in a microfluidic device using dehydrated isoelectric gate, Microchimica Acta, 191, 131, (2024)
  4. R. Wu, M.T. Gilavan, M.A. Akbar, L. Fan, P.R. Selvaganapathy, Direct transformation of polycarbonate to highly conductive and superhydrophobic graphene/graphitic composite by laser writing and its applications, Carbon, 216, 118597, (2024)
  5. M. Darestani-Farahani, F. Ma, V. Patel, P.R. Selvaganapathy, P. Kruse, An ion-selective chemiresistive platform as demonstrated for the detection of nitrogen species in water, Analyst, 148, 5731-5744, (2023)
  6. P. Kruse, S. Angizi, L. Hong, X. Huang, P.R. Selvaganapathy, Graphene versus concentrated aqueous electrolytes: The role of the electrochemical double layer in the determining the screening length of an electrolyte, npj 2D Materials and Applications, 7, 67, (2023)
  7. X. Mei, Q. Fang, P.R. Selvaganapathy, Three-dimensional oxygen concentration monitoring in hydrogels using low-cost phosphorescence lifetime imaging for tissue engineering, Biomed. Opt. Exp. 14, 4759-4774 (2023)
  8. R. Wu, P.R. Selvaganapathy, Porous biocompatible colorimetric nanofiber-based sensor for selective ammonia detection on personal wearable protective equipment, Sens. & Act., Chem., 393, 134270 (2023)
  9. L. Fan, R. Wu, J.J. Huang, P.R. Selvaganapathy, One-step fabrication of the novel electrochemical sensing platform for the ultrasensitive determination of Microcystin-LR, Sens. & Act., Chem., 390, 133961 (2023)
  10. V. Patel, M.A. Akbar, P. Kruse, P.R. Selvaganapathy, A reagent-free phosphate chemiresistive sensor using carbon nanotubes functionalized with crystal violet, Analyst, 148, 3551 – 3558 (2023)
  11. L. Fan, R. Wu, V. Patel, J.J. Huang, P.R. Selvaganapathy, Solid-state, reagent-free and one-step laser-induced synthesis of graphene-supported metal nanocomposites from metal leaves and application to glucose sensing, Analytica Chimica Acta, 1264, 341248, (2023)
  12. R. Ghaemi, M. Acker, A. Stosic, R. Jacobs, P.R. Selvaganapathy, Bending Drosophila larva using a microfluidic device enables imaging of its brain and nervous systems at single neuronal resolution, Lab on a Chip, 23, 295 – 305 (2023)
  13. S. Shariari, P.R. Selvaganapathy, Integration of hydrogels into microfluidic devices with porous membranes as scaffolds enables their drying and reconstitution, Biomicrofluidics, 16, 054108, (2022)
  14. R. Wu, P. Mudzi, D. Firouzi, C.Y. Ching, P.R. Selvaganapathy, Development of high-performance hypodermic needle penetration resistance flexible cotton fabric using patterned thermoplastic adhesive film, Materials Today Communications, 33, 104444, (2022)
  15. S. Damodara, J. Arora, D.J. Dwivedi, P.C. Liaw, A.E. Fox-Robichaud, P.R. Selvaganapathy, Microfluidic device for single step measurement of protein C in plasma samples for sepsis prognosis, Lab on a Chip, 22, 2566 – 2577, (2022)
  16. V. Patel, P. Kruse, P.R. Selvaganapathy, Solid state sensors for phosphate detection in environmental and medical diagnostics, Journal of the Electrochemical Society, 169, 077505, (2022)
  17. S. Angizi, P.R. Selvaganapathy, P. Kruse, Graphene-Silicon schottky devices for operation in aqueous environments: Device performance and sensing application, Carbon, 194, 140-153, (2022)
  18. M. Fathalla, P. R. Selvaganapathy, Colorimetric detection of heavy metal ions using super absorptive hydrogels and evaporative concentration for water quality monitoring, ACS ES&T Water, 2, 658-666 (2022)
  19. D. Saha, S. Angizi, M. Darestani-Farahani, J. Dalmieda, P.R. Selvaganapathy, P. Kruse, Tuning the chemical and mechanical properties of conductive MoS2 thin films by surface modification with aryl diazonium salts, Langmuir, 38, 3666-3675 (2022)
  20. F.C. Li, A. Shamsabadi, P.R. Selvaganapathy, A. Kishen, Engineering a novel stem cells from apical papilla-macrophages organoid for regenerative endodontics, Journal of Endodontics, 48, 741-748 (2022) (Best paper award – Regenerative Endodontics)
  21. S. Damodara, J. Arora, P.C. Liaw, A.E. Fox-Robichaud, P. Ravi Selvaganapathy, Single-step measurement of cell free DNA for sepsis prognosis using a thread-based microfluidic device, Microchimica Acta, 189, 1-10, (2022)
  22. I. Hassan, P.R. Selvaganapathy, Microfluidic printheads for highly switchable multimaterial 3D printing of soft materials, Advanced Materials Technologies, 2101709 (2022)
  23. V. Patel, D. Saha, P. Kruse, P.R. Selvaganapathy, Reagent-free hydrogen peroxide sensing using carbon nanotube chemiresistors with electropolymerized crystal violet, ACS Applied Nano Materials, 5, 3957-3966 (2022)
  24. D. Firouzi, P. Mudzi, C.Y. Ching, T. Farncombe, P.R. Selvaganapathy, Use of pressure sensitive adhesives to create flexible ballistic composite laminates from UHMWPE fabric, Composite Structures, 287, 115362, (2022)
  25. P. Mudzi, R. Wu, D. Firouzi, C.Y. Ching, T. Francombe, P.R. Selvaganapathy, Use of patterned thermoplastic hot film to create flexible ballistic composite laminates from UHMWPE fabric, Materials & Design, 214, 110403, (2022)
  26. A.Z. Laserna, S. Angizi, M. Aliakbar, R. Divigalpithiya, P.R. Selvaganapathy, P. Kruse, Detection of free chlorine in water using graphene-like carbon based chemiresistive sensors, RSC Advances, 12, 2485-2496, (2022)
  27. V. Patel, P. Kruse, P.R. Selvaganapathy, A xurography based rapid prototyping method to fabricate and low-cost high quality metal thin film micropatterns using metal leaves, Materials Today Communications, 30, 103132, (2022)
  28. I. Hassan, P.R. Selvaganapathy, A microfluidic printhead with integrated hybrid mixing by sequential injection for multimaterial 3D printing, Additive Manufacturing, 50, 102559, (2022)
  29. S. Sayed, P.R. Selvaganapathy, High resolution fabrication of nano patterns by multi-step iterative miniaturization of hot embossed pre-stressed polymer films and constrained shrinking, Microsystems and Nanoengineering, 8, 20, (2022)
  30. A. Shamsabadi, P.R. Selvaganapathy, Engineering murine adipocytes and skeletal muscle cells in meat-like constructs using self-assembled layer-by-layer biofabrication: A platform for development of cultivated meat, Cells Tissues Organs, 211, 82-90, (2022) (invited for special issue)
  31. S. Damodara, Y. Zhu, P.R. Selvaganapathy, Patterned threads as solid-state reagent storage and delivery medium for automated periodic colorimetric monitoring of the environment, Microfluidics Nanofluidics, 25, 1-13 (2021)
  32. S. Sayed, P.R. Selvaganapathy, Constrained shrinking of nanoimprinted pre-stressed polymer films to achieve programmable, high-resolution, miniatur

ized nanopatterns, Nanotechnology, 32, 505301, (2021)

  1. M. Sliwiak, R. Bui, M.A. Brook, P.R. Selvaganapathy, 3D printing of highly reactive silicones using inkjet type droplet ejection and free space droplet merging and reaction, Additive Manufacturing, 46, 102099, (2021)
  2. V. Patel, P. Kruse, P.R. Selvaganapathy, Solid state sensors for hydrogen peroxide detection, Biosensors, 11, 9, (2021)
  3. S. Damodara, D.J. Dwivedi, P.C. Liaw, A.E. Fox-Robichaud, P. Ravi Selvaganapathy, Single step separation and concentration of biomarker proteins using agarose based miniaturized isoelectric gates for point of care diagnostics, Sens. & Act. B: Chem., 330, 129265, (2021)
  4. S. Sayed, P.R. Selvaganapathy, Multi-step proportional miniaturization to nanoscale dimensions using pre-stressed polymer films, Nanoscale Advances, 2, 5461 – 5467 (2020)
  5. A. Shamsabadi, P.R. Selvaganapathy, π-SACS: pH induced self-assembled cell sheets without the need for modified surfaces, ACS Biomaterials Science and Engineering, 6, 5346-5356, (2020)
  6. M. Dabaghi, N. Rochow, N. Saraei, G. Fusch, S. Monkman, K. Da, A. Shamsabadi, J.L. Brash, D. Predescu, K. Delaney, C. Fusch, P. R. Selvaganapathy, A pumpless microfluidic neonatal lung assist device for support of preterm neonates in respiratory distress, Advanced Science, 7, 2001860 (2020)
  7. A. Shamsabadi, P.R. Selvaganapathy, Tissue in a Tube: 3D In vitro tissue constructs with integrated multimodal environmental stimulation, Materials Today Bio, 7, 100070, (2020)
  8. M. Dabaghi, N. Rochow, N. Saraei, R.K. Mahendran, G. Fusch, A.K. Chan, J.L. Brash, C. Fusch, P. R. Selvaganapathy, Miniaturization of artificial lungs towards portability, Advanced Materials Technologies, 5, 2000136, (2020) (highlighted by an invited article in Advanced Science News)
  9. A. Shamsabadi, P.R. Selvaganapathy, A 3D self assembled in vitro model to simulate direct and indirect interactions between adipocytes and skeletal muscle cells, Advanced Biosystems, 4, e2000034, (2020)
  10. N. Xiao, R. Wu, J.J Huang, P.R. Selvaganapathy, Anode surface modification regulates biofilm community population and the performance of micro-MFC based biochemical oxygen demand sensor, Chem. Engg. Sci., 221, 115691, (2020)
  11. N. Xiao, P.R. Selvaganapathy, R. Wu, J.J Huang, Influence of wastewater microbial community on the performance of miniaturized microbial fuel cell biosensor, Bioresource Technology, 302, 122777, (2020)
  12. N. Xiao, R. Wu, J.J. Huang, P.R. Selvaganapathy, Development of a xurographically fabricated miniaturized low-cost, high-performance microbial fuel cell and its application for sensing biological oxygen demand, Sensors & Actuators B: Chem., 304, 127432, (2020)
  13. M. Dabaghi, N. Saraei, G. Fusch, N. Rochow, J. Brash, C. Fusch, P. R. Selvaganapathy, An ultra-thin, all PDMS-based microfluidic lung assist device with high oxygenation capacity, Biomicrofluidics, 13, 034116 (2019)
  14. A. Shahin-Shamsabadi, P. Ravi Selvaganapathy, A rapid fabrication technique for self-assembled collagen-based multicellular heterogeneous 3D tissue constructs, Acta Biomaterialia, 92, 172-183, (2019)
  15. A. Mohammadzadeh, A. Fox-Robichaud, P.R. Selvaganapathy, Rapid and inexpensive method for fabrication and integration of electrodes in microfluidic devices, J. MEMS, 28, 597-605, (2019)
  16. A. Shahin-Shamsabadi, P. Ravi Selvaganapathy, ExCeL: Combining Extrusion Printing on Cellulose Scaffolds with Lamination to Create In Vitro Biological Models, Biofabrication, 11, 035002, (2019)
  17. R. Attalla, E. Puersten, N. Jain, P.R. Selvaganapathy, 3D Bioprinting of Heterogeneous Bi- and Tri-layered Hollow Channels within Gel Scaffolds using Scalable Multi-Axial Microfluidic Extrusion Nozzle, Biofabrication, 11, 015012, (2019)
  18. A. Mohammadzadeh, A. Fox-Robichaud, P.R. Selvaganapathy, Rapid and inexpensive method for fabrication of multi-material multi-layer microfluidic devices, J. Micromech. Microeng., 29, 015013, (2019)
  19. M. Dabaghi, N. Saraei, G. Fusch, N. Rochow, J.L. Brash, C. Fusch, P. R. Selvaganapathy, An ultra-thin highly flexible microfluidic device for blood oxygenation, Lab on a Chip, 18, 3780 – 3789 (2018) (featured on the cover)
  20. S. Zheng, M. Zlatin, P. Ravi Selvaganapathy, M.A. Brook, Multiple modulus silicone elastomers using 3D extrusion printing of low viscosity inks, Additive Manufacturing, 24, 86-92, (2018)
  21. D. Firouzi, M.K. Russel, S.N. Rizvi, C.Y. Ching, P.R. Selvaganapathy, Development of flexible particle-laden elastomeric textiles with improved penetration resistance to hypodermic needles, Materials and Design, 156, 419-428, (2018)
  22. M. Wong, M.A. Green, S. Shawky, A. Aryasomyajula, T. Ewart, P. R Selvaganapathy, S. Raha, Extracellular matrix (ECM) surface regulates self-assembly of three-dimensional placental trophoblast spheroids, PLOS ONE, 13, e0199632, (2018)
  23. M. Dabaghi, G. Fusch, N. Saraei, N. Rochow, J. Brash, C. Fusch, P. R. Selvaganapathy, An artificial placenta type microfluidic blood oxygenator with double-sided gas transfer microchannels and its integration as a neonatal lung assist device, Biomicrofluidics, 12, 044101, (2018) (chosen as the Editor’s Pick)
  24. R. Attalla, C.S. Ling, P.R. Selvaganapathy, Silicon carbide nanoparticles as an effective bioadhesive to bond collagen containing composite gel layers for tissue engineering applications, Advanced Healthcare Materials, 7, 1701385 (2018) (featured on the cover)

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